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introduction and aims: in order to prevent liver cirrhosis and hepatocellular carcinoma in later life, it is essential to prevent hepatitis b virus (hbv) infection in infants. despite the availability of an effective vaccine, hepatitis b still continues to be a significant health problem. the aim of this study is to reveal the efficacy of passive and active immunoprophylaxis for preventing peri...

Background: The HLA class I molecules serve as ligands for both T cell receptors and killer cell immunoglobulin-like receptors (KIRs). Objective: We investigated the HLAC and HLA-Bw4 alleles as well as KIRs expression on CD56 positive lymphocytes to evaluate whether these genes and molecules could influence Ankylosing spondylitis (AS) susceptibility, alone or in combination. Methods: We typed 4...

B-cell activation induced by crosslinking of surface immunoglobulin is known to stimulate hydrolysis of phosphatidylinositol to diacylglycerol and inositol trisphosphate. We now provide evidence that alternative pathways of activation may also be recruited during such activation. We utilized depletion of protein kinase C activity to determine whether this enzyme is required under all conditions...

BACKGROUND AND PURPOSE Major hepatotropic viruses continue to be important causes of acute viral hepatitis in developing countries. This work was carried out to detect the seroprevalence of hepatitis E virus (HEV) markers in children with acute viral hepatitis due to hepatotropic viruses (A, B and C) and non-A, non-B, non-C acute hepatitis, and to ascertain the influence of HEV superinfection i...

conclusions hepatitis b core antibody immunoglobulin m positivity is different in healthy blood donors of different countries according to the prevalence of chronic hepatitis b and its vaccination. based on the current study findings, all positive samples of hepatitis b core antibody in iranian blood banks should be considered as candidates for occult hepatitis b not just the window period infe...